ABSTRACT
Introduction: Diabetes is a serious metabolic disease with chronic and acute complications, especially atherosclerosis. The increase of blood homocystein level is obviously related to blood injuries\u2019 in a number of diseases including diabetes. In Vietnam, blood Homocystein in Diabetics has not been comprehensively studied. \r\n', u'Objectives: The study was conducted with two surveyed groups. Determination of blood homocystein concentration in type 2 diabetics in comparison with a group of normal people. \r\n', u'Subjects and method: The study was conducted on a sample of 57 type 2 diabetics according to WHO-2001 standards and a group of 46 normal people. Concentration of blood homocystein was assayed by a competition fluorescence immunoassay, and by other experiments according to normal biochemical methods.\r\n', u'Results: The tHcy concentration in diabetics is 12.19 \xb1 3.47 mmo/L and in the normal group is 7.87 \xb1 2.26 IJmo/L. \r\n', u'Conclusion: The tHcy concentration in the 57 type 2 diabetics group has a statistically increasing mean in comparison with the normal group for both men and women. However, there is no comparative difference in the tHcy concentration of diabetics in gender and age categories. \r\n', u'
ABSTRACT
Background: Macro vascular disease is a frequent complication and can rapidly progress in type 2 diabetics. The increase of blood homocysteine (Hcy) level is obviously related to an injury of blood vessels in certain types of diseases including diabetes. It is necessary to determine blood Hcy concentrations and find out its role in relation to other tests in type 2 diabetics. Objectives: (1) Determination of blood HbA1C concentration, urine micro albumin, and flow mediated dilatation (FMD) in type 2 diabetics. (2) Discover any relations between blood Hcy levels and other parameters in type 2 diabetics. Subjects and method: The prospective, descriptive, cross-sectional study was carried out on 57 type 2 diabetics diagnosed by WHO 2001 criteria. The concentrations of blood Hcy of all participants were assayed by a competition fluorescence immunoassay. Results: Concentrations of blood HbA1C in patients without and with controlling blood glucose were 10.6 +/- 2.2% and 7.2 +/- 0.3%, respectively. In type 2 diabetics, 35.1% of patients had positive micro-albuminuria (MAU}. FMD of patients with and without vascular damage were 4.19 +/- 1.83% and 8065 +/- 2.1%, respectively. The average concentration of blood Hcy in 57 type 2 diabetics was 12.19 +/- 3.47 micromol/L. Conclusion: Concentrations of blood Hcy in type 2 diabetics without controlling blood glucose were higher than those in the group with controlled blood glucose, but not significantly. Concentrations of blood Hcy between patients with MAU (-) and MAU (+) were significantly different. There is a reverse linear correlation between blood Hcy and FMD.